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JACC Basic Transl Sci. 2017 Aug 28;2(4):418-430. doi: 10.1016/j.jacbts.2017.06.005. eCollection 2017 Aug.

The IL-1β Antibody Gevokizumab Limits Cardiac Remodeling and Coronary Dysfunction in Rats With Heart Failure.

Harouki N1,2,3, Nicol L1,2,3,4, Remy-Jouet I1,2,3, Henry JP1,2,3, Dumesnil A1,2,3, Lejeune A1,2,3, Renet S1,2,3, Golding F1,2,3, Djerada Z1,2,3,5, Wecker D6, Bolduc V7, Bouly M7, Roussel J7, Richard V1,2,3, Mulder P1,2,3,4.

Author information

1
INSERM U1096, Rouen, France.
2
Normandy University, IRIB, Rouen, France.
3
Unité de formation et de recherche de Médecine et Pharmacie, Rouen University, Rouen, France.
4
Plateau d'Imagerie CardioThoracique de l'Université de Rouen, Rouen, France.
5
Pharmacology Department, Centre Hospitalier Universitaire de Reims, Reims, France.
6
Bruker Biospin MRI GMBH, Ettlingen, Germany.
7
Institut de Recherches Internationales Servier, Suresnes, France.

Abstract

This study reports preclinical data showing that the interleukin (IL)-1β modulation is a new promising target in the pathophysiological context of heart failure. Indeed, in nondiabetic Wistar and diabetic Goto-Kakizaki rats with chronic heart failure induced by myocardial infarction, administration of the IL-1β antibody gevokizumab improves 'surrogate' markers of survival (i.e., left ventricular remodeling, hemodynamics, and function as well as coronary function). However, whether IL-1β modulation per se or in combination with standard treatments of heart failure improves long-term outcome in human heart failure remains to be determined.

KEYWORDS:

GK, Goto-Kakisaki; I/R, ischemia/reperfusion; IL, interleukin; IL-1β; LV, left ventricle/ventricular; LVEDP, left ventricular end-diastolic pressure; LVEDPV, left ventricular end-diastolic pressure–volume relationship; LVESP, left ventricular end-systolic pressure; LVESPVR, left ventricular end-systolic pressure–volume relationship; ROS, reactive oxygen species; SOD, superoxide dismutase; cardiovascular function; heart failure; ischemia/reperfusion

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