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Nat Chem Biol. 2018 Sep;14(9):841-843. doi: 10.1038/s41589-018-0101-9. Epub 2018 Jul 30.

Gramibactin is a bacterial siderophore with a diazeniumdiolate ligand system.

Author information

1
Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany.
2
Institute for Inorganic and Analytical Chemistry, Friedrich Schiller University, Jena, Germany.
3
Department of Cell and Molecular Biology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany.
4
Friedrich Schiller University, Faculty of Biology and Pharmacy, Jena, Germany.
5
Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany. christian.hertweck@hki-jena.de.
6
Friedrich Schiller University, Faculty of Biology and Pharmacy, Jena, Germany. christian.hertweck@hki-jena.de.

Abstract

Genome mining and chemical analyses revealed that rhizosphere bacteria (Paraburkholderia graminis) produce a new type of siderophore, gramibactin, a lipodepsipeptide that efficiently binds iron with a log╬▓ value of 27.6. Complexation-induced proton NMR chemical shifts show that the unusual N-nitrosohydroxylamine (diazeniumdiolate) moieties participate in metal binding. Gramibactin biosynthesis genes are conserved in numerous plant-associated bacteria associated with rice, wheat, and maize, which may utilize iron from the complex.

PMID:
30061716
DOI:
10.1038/s41589-018-0101-9

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