Send to

Choose Destination
Sci Rep. 2018 Jul 30;8(1):11459. doi: 10.1038/s41598-018-29616-y.

Vitamin K supplementation during pregnancy for improving outcomes: a systematic review and meta-analysis.

Author information

Department of Health Policy, National Center for Child Health and Development, Tokyo, Japan.
Population Health Research Institute, A Joint Institute of McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.
Global Health Nursing, St. Luke's International University, Graduate School of Nursing Sciences, Tokyo, Japan.
Department of Health Policy, National Center for Child Health and Development, Tokyo, Japan.
Department of Food Science and Nutrition Faculty of Human Life and Environmental Sciences, Nagoya Women's University, Aichi, Japan.


To study supplementation effect of vitamin K (VK) alone or combined with other nutrients administered to pregnant women, we searched Cochrane Pregnancy and Childbirth Group's Trials Register (till 22 January 2016, updated on 28 February 2018) including other resources. Two review authors independently assessed randomised or quasi-randomised controlled trials for inclusion, data extraction, accuracy, and risk of bias. We included older trials from high-income countries (six; 21,493 women-newborns), judged mostly as high or unclear bias risk. We could not assess high-risk e.g. epileptic women, but healthy women (different gestational ages) received varying VK dosages and duration. We meta-analysed neonatal bleeding (RR 1.16, 95% CI 0.59 to 2.29; Pā€‰=ā€‰0.67) and maternal plasma VK1 (MD 2.46, 95% CI 0.98 to 3.93; Pā€‰=ā€‰0.001). We found many outcomes were un-assessed e.g. perinatal death, maternal bleeding, healthcare utilization. Mostly newborns were included where VK found significantly effective for e.g. serum VK (mother-newborn), maternal breast milk VK. Few trials reported neonatal adverse side effects. The GRADE evidence quality was very low i.e. neonatal bleeding, neonatal jaundice, maternal plasma VK1. The intervention was favourable for maternal sera VK1 but remained uncertain for neonatal bleeding and other outcomes. The existing literature gaps warrant future investigations on un-assessed or inadequately reported outcomes.

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center