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Anticancer Res. 2018 Aug;38(8):4883-4888. doi: 10.21873/anticanres.12802.

Controlling Nutritional Status (CONUT) Score Is a Prognostic Marker in Metastatic Colorectal Cancer Patients Receiving First-line Chemotherapy.

Author information

1
Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
2
Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan hdobaba@kumamoto-u.ac.jp.

Abstract

BACKGROUND/AIM:

The Controlling Nutritional Status (CONUT) score is a useful nutritional evaluation, that is calculated from serum albumin, total cholesterol concentrations, and total lymphocyte count. This study aimed to investigate the association between the CONUT score and prognosis in patients with metastatic colorectal cancer (mCRC).

PATIENTS AND METHODS:

The CONUT score was retrospectively calculated in 211 patients with mCRC receiving first-line chemotherapy. The patients were divided into three groups: the CONUT low-group (0-1), intermediate-group (2-4), and high-group (5-). The associations of the CONUT score with clinicopathological factors and survival outcomes were evaluated.

RESULTS:

The higher CONUT score was significantly associated with synchronous metastases, and no primary tumor resection. The higher CONUT score group showed a significant shorter progression-free survival (log-rank p<0.05) and overall survival (log-rank p<0.001).

CONCLUSION:

The CONUT score is a useful prognostic marker for predicting survival outcomes of patients with mCRC.

KEYWORDS:

CONUT score; colorectal cancer; metastasis; prognostic marker

PMID:
30061264
DOI:
10.21873/anticanres.12802
[Indexed for MEDLINE]

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