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Vet Res. 2018 Jul 31;49(1):64. doi: 10.1186/s13567-018-0560-8.

Vaccines as alternatives to antibiotics for food producing animals. Part 1: challenges and needs.

Author information

1
The Pew Charitable Trusts, 901 E Street NW, Washington, DC, 20004, USA. khoelzer@pewtrusts.org.
2
Ohio Agriculture and Research Development Center, Animal Sciences, Ohio State University, 202 Gerlaugh Hall, 1680 Madison Ave., Wooster, OH, 44691, USA.
3
Pathobiology and Population Sciences, Royal Veterinary College, University of London, Hawkshead Lane, North Mymms, Hertfordshire, AL9 7TA, UK.
4
Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salsiburylaan 133, B-9820, Merelbeke, Belgium.
5
School of Biological Sciences, Royal Holloway University of London, Egham, Surrey, TW20 0EX, UK.
6
Science and New Technologies Department, World Organisation for Animal Health (OIE), 12 Rue de Prony, 75017, Paris, France.
7
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salsiburylaan 133, B-9820, Merelbeke, Belgium.
8
Elanco Animal Health, 2500 Innovation Way, Greenfield, IN, USA.
9
Merial, 29 Avenue Tony Garnier, F-69007, Lyon, France.
10
RIPAC-LABOR GmbH, Am Mühlenberg 11, 14476, Potsdam, Germany.
11
MSD, 2 Giralda Farms, Madison, NJ, USA.
12
The Pew Charitable Trusts, 901 E Street NW, Washington, DC, 20004, USA.
13
Office of National Programs, Agricultural Research Service, USDA, Sunnyside Ave, 5601, Beltsville, MD, USA.

Abstract

Vaccines and other alternative products can help minimize the need for antibiotics by preventing and controlling infectious diseases in animal populations, and are central to the future success of animal agriculture. To assess scientific advancements related to alternatives to antibiotics and provide actionable strategies to support their development, the United States Department of Agriculture, with support from the World Organisation for Animal Health, organized the second International Symposium on Alternatives to Antibiotics. It focused on six key areas: vaccines; microbial-derived products; non-nutritive phytochemicals; immune-related products; chemicals, enzymes, and innovative drugs; and regulatory pathways to enable the development and licensure of alternatives to antibiotics. This article, part of a two-part series, synthesizes and expands on the expert panel discussions regarding opportunities, challenges and needs for the development of vaccines that may reduce the need for use of antibiotics in animals; new approaches and potential solutions will be discussed in part 2 of this series. Vaccines are widely used to prevent infections in food animals. Various studies have demonstrated that their animal agricultural use can lead to significant reductions in antibiotic consumption, making them promising alternatives to antibiotics. To be widely used in food producing animals, vaccines have to be safe, effective, easy to use, and cost-effective. Many current vaccines fall short in one or more of these respects. Scientific advancements may allow many of these limitations to be overcome, but progress is funding-dependent. Research will have to be prioritized to ensure scarce public resources are dedicated to areas of potentially greatest impact first, and private investments into vaccine development constantly compete with other investment opportunities. Although vaccines have the potential to improve animal health, safeguard agricultural productivity, and reduce antibiotic consumption and resulting resistance risks, targeted research and development investments and concerted efforts by all affected are needed to realize that potential.

PMID:
30060757
PMCID:
PMC6066911
DOI:
10.1186/s13567-018-0560-8
[Indexed for MEDLINE]
Free PMC Article

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