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Molecules. 2018 Jul 29;23(8). pii: E1894. doi: 10.3390/molecules23081894.

Effects of Mogrosides on High-Fat-Diet-Induced Obesity and Nonalcoholic Fatty Liver Disease in Mice.

Zhang X1,2, Song Y3, Ding Y4,5, Wang W6,7, Liao L8,9, Zhong J10,11, Sun P12,13, Lei F14, Zhang Y15,16,17, Xie W18,19,20.

Author information

1
Department of Chemistry, Tsinghua University, Beijing 100084, China. zxb17@mails.tsinghua.edu.cn.
2
State Key Laboratory of Chemical Oncogenomics, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China. zxb17@mails.tsinghua.edu.cn.
3
Guilin Layn Natural Ingredients Corp., Guilin 541100, China. song.yunfei@layn.com.cn.
4
Department of Chemistry, Tsinghua University, Beijing 100084, China. 15139915181@163.com.
5
State Key Laboratory of Chemical Oncogenomics, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China. 15139915181@163.com.
6
Open FIESTA Center, Tsinghua University, Shenzhen 518055, China. kappa33wei@live.com.
7
Key Lab in Healthy Science and Technology, Division of Life Science, Graduate School at Shenzhen; Tsinghua University, Shenzhen 518055, China. kappa33wei@live.com.
8
Open FIESTA Center, Tsinghua University, Shenzhen 518055, China. 15602927350@163.com.
9
Key Lab in Healthy Science and Technology, Division of Life Science, Graduate School at Shenzhen; Tsinghua University, Shenzhen 518055, China. 15602927350@163.com.
10
Open FIESTA Center, Tsinghua University, Shenzhen 518055, China. zhongjin1996@163.com.
11
Key Lab in Healthy Science and Technology, Division of Life Science, Graduate School at Shenzhen; Tsinghua University, Shenzhen 518055, China. zhongjin1996@163.com.
12
Open FIESTA Center, Tsinghua University, Shenzhen 518055, China. pb_sun@foxmail.com.
13
Key Lab in Healthy Science and Technology, Division of Life Science, Graduate School at Shenzhen; Tsinghua University, Shenzhen 518055, China. pb_sun@foxmail.com.
14
Laboratory of Pharmaceutical Science, School of Life Science, School of Medicine, Tsinghua University, Beijing 100084, China. lifn@163.com.
15
State Key Laboratory of Chemical Oncogenomics, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China. zhangyo@sz.tsinghua.edu.cn.
16
Open FIESTA Center, Tsinghua University, Shenzhen 518055, China. zhangyo@sz.tsinghua.edu.cn.
17
Key Lab in Healthy Science and Technology, Division of Life Science, Graduate School at Shenzhen; Tsinghua University, Shenzhen 518055, China. zhangyo@sz.tsinghua.edu.cn.
18
State Key Laboratory of Chemical Oncogenomics, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China. xiewd@sz.tsinghua.edu.cn.
19
Open FIESTA Center, Tsinghua University, Shenzhen 518055, China. xiewd@sz.tsinghua.edu.cn.
20
Key Lab in Healthy Science and Technology, Division of Life Science, Graduate School at Shenzhen; Tsinghua University, Shenzhen 518055, China. xiewd@sz.tsinghua.edu.cn.

Abstract

Obesity and nonalcoholic fatty liver disease (NAFLD) are highly prevalent and cause numerous metabolic diseases. However, drugs for the prevention and treatment of obesity and NAFLD remain unavailable. In this study, we investigated the effects of mogrosides (luo han guo, LH) in Siraitia grosvenorii saponins on high-fat-diet-induced obesity and NAFLD in mice. We found that compared with the negative control, LH reduced body and liver weight. LH also decreased fat accumulation and increased AMP-activated protein kinase (AMPK) phosphorylation (pAMPK) levels in mouse livers. We also found that high-purity mogroside V upregulated pAMPK expression in HepG2 cells. In addition, high-purity mogroside V inhibited reactive oxygen species production and upregulated sequestosome-1 (SQSTM1, p62) expression in THP-1 cells. These results suggest that LH may affect obesity and NAFLD by enhancing fat metabolism and antioxidative defenses. Mogroside V may be a main component of LH. However, the exact molecular mechanisms and active components responsible for the inhibitory effects of LH on obesity and NAFLD require further investigation.

KEYWORDS:

AMPK; Siraitia grosvenorii; mogrosides; nonalcoholic fatty liver disease; obesity; p62

PMID:
30060618
PMCID:
PMC6222773
DOI:
10.3390/molecules23081894
[Indexed for MEDLINE]
Free PMC Article

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