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Molecules. 2018 Jul 28;23(8). pii: E1892. doi: 10.3390/molecules23081892.

The Phytochemical and Biological Investigation of Jatropha pelargoniifolia Root Native to the Kingdom of Saudi Arabia.

Author information

1
Department of Pharmacognosy, Faculty of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. hati@ksu.edu.sa.
2
Department of Pharmacognosy, Faculty of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. aelgamel@ksu.edu.sa.
3
Department of Pharmacognosy, College of Pharmacy, Mansoura University, El-Mansoura 35516, Egypt. aelgamel@ksu.edu.sa.
4
Technical Biochemistry, TU Dortmund University, Emil-Figge-Strasse 66, D-44227 Dortmund, Germany. oliver.kayser@tu-dortmund.de.
5
Department of Pharmacognosy, Faculty of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. afahmed@ksu.edu.sa.
6
Department of Pharmacognosy, College of Pharmacy, Mansoura University, El-Mansoura 35516, Egypt. afahmed@ksu.edu.sa.

Abstract

Extensive phytochemical analysis of different root fractions of Jatropha pelargoniifolia Courb. (Euphorbiaceae) has resulted in the isolation and identification of 22 secondary metabolites. 6-hydroxy-8-methoxycoumarin-7-O-β-d-glycopyranoside (15) and 2-hydroxymethyl N-methyltryptamine (18) were isolated and identified as new compounds along with the known diterpenoid (1, 3, 4, and 7), triterpenoid (2 and 6), flavonoid (5, 11, 13, 14, and 16), coumarinolignan (810), coumarin (15), pyrimidine (12), indole (17, 18), and tyramine-derived molecules (1922). The anti-inflammatory, analgesic, and antipyretic activities were evaluated for fifteen of the adequately available isolated compounds (16, 811, 13, 14, 16, 21, and 22). Seven (4, 6, 10, 5, 13, 16, and 22) of the tested compounds showed a significant analgesic effect ranging from 40% to 80% at 10 mg/kg in two in vivo models. Compound 1 could also prove its analgesic property (67.21%) when it was evaluated on a third in vivo model at the same dose. The in vitro anti-inflammatory activity was also recorded where all compounds showed the ability to scavenge nitric oxide (NO) radical in a dose-dependent manner. However, eight compounds (1, 4, 5, 6, 10, 13, 16, and 22) out of the fifteen tested compounds exhibited considerable in vivo anti-inflammatory activity which reached 64.91% for compound 10 at a dose of 10 mg/kg. Moreover, the tested compounds exhibited an antipyretic effect in a yeast-induced hyperthermia in mice. The activity was found to be highly pronounced with compounds 1, 5, 6, 10, 13, and 16 which decreased the rectal temperature to about 37 °C after 2 h of the induced hyperthermia (~39 °C) at a dose of 10 mg/kg. This study could provide scientific evidence for the traditional use of J. pelargoniifolia as an anti-inflammatory, analgesic, and antipyretic.

KEYWORDS:

Jatropha pelargoniifolia; alkaloids; analgesic; anti-inflammatory; antipyretic; coumarinolignans; diterpenes; flavonoids

PMID:
30060587
PMCID:
PMC6222854
DOI:
10.3390/molecules23081892
[Indexed for MEDLINE]
Free PMC Article

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