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Anal Sci. 2018 Sep 10;34(9):1055-1059. doi: 10.2116/analsci.18SCN01. Epub 2018 Jul 27.

Mass Spectrometric Imaging of GABA in the Drosophila melanogaster Adult Head.

Author information

1
Department of Biotechnology, Graduate School of Engineering, Osaka University.
2
Institute of Applied Microbiology, Aachen Biology and Biotechnology, RWTH Aachen University.
3
Department of Applied Biology, Kyoto Institute of Technology.

Abstract

Drosophila melanogaster is a model organism in neurodegenerative disease research. In neurodegenerative study, the direct spatial information of neurotransmitters such as γ-aminobutyric acid (GABA) in the brain of Drosophila melanogaster is important to understand the role of GABA. Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) is an attractive method for direct visualization of neurotransmitters. In this paper, we describe methods to visualize GABA in the brain and head of Drosophila melanogaster using MALDI-IMS.

KEYWORDS:

Drosophila melanogaster; GABA; Imaging mass spectrometry; on-tissue derivatization

PMID:
30058603
DOI:
10.2116/analsci.18SCN01
[Indexed for MEDLINE]
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