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Endocr J. 2018 Oct 29;65(10):1029-1037. doi: 10.1507/endocrj.EJ18-0166. Epub 2018 Jul 27.

Vitamin D in Hashimoto's thyroiditis and its relationship with thyroid function and inflammatory status.

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Endocrinology Division, Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, San Paulo, Brazil.
Biology Institute, University of Campinas, Campinas, San Paulo, Brazil.
Metabolic Unit, Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas Campinas, San Paulo, Brazil.


Several studies have shown the correlation between vitamin D [25(OH)D] deficiency and thyroid autoimmunity and reducing of thyroid autoantibodies in patients with normal levels of vitamin D combining with thyroid hormone replacement. However, other authors not agree with this association. It is still unclear whether the low 25(OH)D levels are the result of HT disease or a part of its cause. We studied 88 patients with HT regarding vitamin D status and thyroid autoimmunity markers as well as the relationship with cytokines produced by Th1, Th2, and Th17 cells compared with a control group of 71 euthyroid healthy subjects. The present study demonstrated that vitamin D concentrations were similar in patients HT and the control group. The reduction of free T4 levels was a predictor of vitamin D insufficiency for Hashimoto's thyroiditis, but not for the control group. Lower concentrations of TNF-α was a predictor of lower levels of vitamin D. Differences in the association between HT and vitamin D insufficiency remain unresolved in the literature. The thyroid hormone status would play a role in the maintenance of vitamin D sufficiency, and its immunomodulatory role would influence the presence of autoimmune thyroid disease. The positive correlation between free T4 and vitamin D concentrations suggests that adequate levothyroxine replacement in HT would be an essential factor in maintaining vitamin D at sufficient levels.


Autoimmunity; Cytokines; Hashimoto’s thyroiditis; Vitamin D

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