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Endocr J. 2018 Oct 29;65(10):1029-1037. doi: 10.1507/endocrj.EJ18-0166. Epub 2018 Jul 27.

Vitamin D in Hashimoto's thyroiditis and its relationship with thyroid function and inflammatory status.

Author information

1
Endocrinology Division, Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, San Paulo, Brazil.
2
Biology Institute, University of Campinas, Campinas, San Paulo, Brazil.
3
Metabolic Unit, Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas Campinas, San Paulo, Brazil.

Abstract

Several studies have shown the correlation between vitamin D [25(OH)D] deficiency and thyroid autoimmunity and reducing of thyroid autoantibodies in patients with normal levels of vitamin D combining with thyroid hormone replacement. However, other authors not agree with this association. It is still unclear whether the low 25(OH)D levels are the result of HT disease or a part of its cause. We studied 88 patients with HT regarding vitamin D status and thyroid autoimmunity markers as well as the relationship with cytokines produced by Th1, Th2, and Th17 cells compared with a control group of 71 euthyroid healthy subjects. The present study demonstrated that vitamin D concentrations were similar in patients HT and the control group. The reduction of free T4 levels was a predictor of vitamin D insufficiency for Hashimoto's thyroiditis, but not for the control group. Lower concentrations of TNF-α was a predictor of lower levels of vitamin D. Differences in the association between HT and vitamin D insufficiency remain unresolved in the literature. The thyroid hormone status would play a role in the maintenance of vitamin D sufficiency, and its immunomodulatory role would influence the presence of autoimmune thyroid disease. The positive correlation between free T4 and vitamin D concentrations suggests that adequate levothyroxine replacement in HT would be an essential factor in maintaining vitamin D at sufficient levels.

KEYWORDS:

Autoimmunity; Cytokines; Hashimoto’s thyroiditis; Vitamin D

PMID:
30058600
DOI:
10.1507/endocrj.EJ18-0166
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