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Vaccine. 2018 Aug 23;36(35):5222-5225. doi: 10.1016/j.vaccine.2018.07.030. Epub 2018 Jul 26.

Subacute sclerosing panencephalitis mortality, United States, 1979-2016: Vaccine-induced declines in SSPE deaths.

Author information

1
Program in Public Health, University of California, Irvine, CA, United States. Electronic address: lpalliva@uci.edu.
2
Department of Population Health and Disease Prevention, University of California, 653 E. Peltason Drive, Irvine, CA 92697, United States. Electronic address: noymer@uci.edu.

Abstract

Subacute sclerosing panencephalitis (SSPE) is a neurodegenerative disease caused by measles virus. We estimate SSPE age-specific mortality in the United States, 1979-2016. The general decline in SSPE mortality reflects that of measles. Shifts, over time, in SSPE mortality by age echo changes in the age distribution of measles in the 1970s and in the 1989-91 outbreak. The current epidemiological situation is that autochthonous SSPE will disappear in the United States, assuming measles vaccination rates remain high.

KEYWORDS:

Measles; Mortality; SSPE; Subacute sclerosing panencephalitis

PMID:
30057285
DOI:
10.1016/j.vaccine.2018.07.030
[Indexed for MEDLINE]

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