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Trends Neurosci. 2018 Sep;41(9):566-568. doi: 10.1016/j.tins.2018.07.004. Epub 2018 Jul 25.

A dLight-ful New View of Neuromodulation.

Author information

1
Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
2
Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address: talia.lerner@northwestern.edu.

Abstract

Neuromodulators such as dopamine can transform neural circuit function, but the mechanisms underlying such transformations are incompletely understood. A recent study introduced dLight1, a genetically encoded fluorescent dopamine indicator. dLight1 allows the optical measurement of dopamine sensed by isolated target circuits with high spatiotemporal resolution and has unique advantages for the study of neuromodulatory mechanisms.

KEYWORDS:

dopamine; genetically encoded indicators; imaging; neuromodulation

PMID:
30055832
DOI:
10.1016/j.tins.2018.07.004
[Indexed for MEDLINE]

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