Format

Send to

Choose Destination
Brain Behav Immun. 2018 Oct;73:34-40. doi: 10.1016/j.bbi.2018.07.020. Epub 2018 Jul 25.

Characterization of dural sinus-associated lymphatic vasculature in human Alzheimer's dementia subjects.

Author information

1
Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, OR, USA; Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, OR, USA.
2
Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, OR, USA.
3
Department of Pathology, Oregon Health & Science University, Portland, OR, USA.
4
Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR, USA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
5
Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, OR, USA; Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA. Electronic address: iliffj@ohsu.edu.

Abstract

Recent reports describing lymphatic vasculature in the meninges have challenged the traditional understanding of interstitial solute clearance from the central nervous system, although the significance of this finding in human neurological disease remains unclear. To begin to define the role of meningeal lymphatic function in the clearance of interstitial amyloid beta (Aβ), and the contribution that its failure may make to the development of Alzheimer's disease (AD), we examined meningeal tissue from a case series including AD and control subjects by confocal microscopy. Our findings confirm the presence of lymphatic vasculature in the human meninges and indicate that, unlike perivascular efflux pathways in the brain parenchyma in subjects with AD, Aβ is not deposited in or around meningeal lymphatic vessels associated with dural sinuses. Our findings demonstrate that while the meningeal lymphatic vasculature may serve as an efflux route for Aβ from the brain and cerebrospinal fluid, Aβ does not deposit in the walls of meningeal lymphatic vessels in the setting of AD.

KEYWORDS:

Alzheimer’s disease; Amyloid beta; LYVE-1; Lymphatic; Meninges; Podoplanin

PMID:
30055243
PMCID:
PMC6149215
[Available on 2019-10-01]
DOI:
10.1016/j.bbi.2018.07.020
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center