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Adv Drug Deliv Rev. 2018 Jul;132:270-295. doi: 10.1016/j.addr.2018.07.016. Epub 2018 Jul 26.

3D bioprinting of skin tissue: From pre-processing to final product evaluation.

Author information

1
Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore.
2
Department of Mechanical Engineering, National University of Singapore, Singapore.
3
Institute of Medical Biology (IMB), Agency for Science, Technology, and Research (A*STAR), Singapore. Electronic address: kim.robinson@imb.a-star.edu.sg.
4
Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore. Electronic address: chewch@nus.edu.sg.

Abstract

Bioprinted skin tissue has the potential for aiding drug screening, formulation development, clinical transplantation, chemical and cosmetic testing, as well as basic research. Limitations of conventional skin tissue engineering approaches have driven the development of biomimetic skin equivalent via 3D bioprinting. A key hope for bioprinting skin is the improved tissue authenticity over conventional skin equivalent construction, enabling the precise localization of multiple cell types and appendages within a construct. The printing of skin faces challenges broadly associated with general 3D bioprinting, including the selection of cell types and biomaterials, and additionally requires in vitro culture formats that allow for growth at an air-liquid interface. This paper provides a thorough review of current 3D bioprinting technologies used to engineer human skin constructs and presents the overall pipelines of designing a biomimetic artificial skin via 3D bioprinting from the design phase (i.e. pre-processing phase) through the tissue maturation phase (i.e. post-processing) and into final product evaluation for drug screening, development, and drug delivery applications.

KEYWORDS:

3D bioprinting; Artificial skin; Skin tissue engineering; Tissue engineering

PMID:
30055210
DOI:
10.1016/j.addr.2018.07.016

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