Format

Send to

Choose Destination
Nat Commun. 2018 Jul 27;9(1):2957. doi: 10.1038/s41467-018-05188-3.

A framework for enhancing ethical genomic research with Indigenous communities.

Author information

1
Department of Pharmaceutics, University of Washington, 1959 NE Pacific Street, Seattle, 98195, WA, USA.
2
Department of Microbiology, The Ohio State University, 484 W. 12th Ave, Columbus, 43210, OH, USA.
3
Department of Microbial Infection and Immunity, The Ohio State University, 460 West 12th Avenue, Columbus, 43210, OH, USA.
4
Cardiovascular Institute, University of Colorado Anschutz Medical Campus, 12700 E 19th Ave, Aurora, 80045, CO, USA.
5
Interdisciplinary Graduate Program, Vanderbilt University, Nashville, 37235, TN, USA.
6
Department of Natural Sciences, Turtle Mountain Community College, PO Box 340, Belcourt, 58316, ND, USA.
7
Department of Endocrinology and Metabolic Disease, University of California San Diego, 9500 Gilman Drive, San Diego, 92037, CA, USA.
8
Treuman Katz Center for Pediatric Bioethics, Seattle Children's Hospital and Research Institute, 1900 Ninth Avenue, Seattle, 98101, WA, USA. nanibaa@uw.edu.
9
Department of Pediatrics, University of Washington, Seattle, 98101, WA, USA. nanibaa@uw.edu.

Abstract

Integration of genomic technology into healthcare settings establishes new capabilities to predict disease susceptibility and optimize treatment regimes. Yet, Indigenous peoples remain starkly underrepresented in genetic and clinical health research and are unlikely to benefit from such efforts. To foster collaboration with Indigenous communities, we propose six principles for ethical engagement in genomic research: understand existing regulations, foster collaboration, build cultural competency, improve research transparency, support capacity building, and disseminate research findings. Inclusion of underrepresented communities in genomic research has the potential to expand our understanding of genomic influences on health and improve clinical approaches for all populations.

PMID:
30054469
PMCID:
PMC6063854
DOI:
10.1038/s41467-018-05188-3
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center