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Lipids Health Dis. 2018 Jul 27;17(1):175. doi: 10.1186/s12944-018-0810-9.

Antihyperlipidemic efficacy of aqueous extract of Stevia rebaudiana Bertoni in albino rats.

Author information

1
Department of Food Science, Nutrition & Home Economics, Government College University, Faisalabad, Pakistan.
2
Institute of Home and Food Sciences, Faculty of Science and Technology, Government College University, Faisalabad, 38000, Pakistan. rabiaahmad@gcuf.edu.pk.
3
Institute of Home and Food Sciences, Faculty of Science and Technology, Government College University, Faisalabad, 38000, Pakistan.
4
Department of Zoology, Government College University, Faisalabad, 38000, Pakistan.
5
Department of Food Science and Technology, Bahauudin Zakariya University, Multan, 38000, Pakistan.

Abstract

BACKGROUND:

Stevia (Stevia rebaudiana Bertoni) natural, safe, non-toxic, non-caloric sugar substitute is rich source of pharmacologically important glycoside stevioside that is linked to the pathology and complications of hyperlipidemia.

METHODS:

The present research was carried out to explore the anti-hyperlipidemic effect of aqueous extract of Stevia rebaudiana Bertoni leaves in albino rats. For this purpose, hyperlipidemia was induced by administration of Cholesterol (90% E, Appli Chem, Darmstadt, Germany) mixed at dose of 400 mg/kg body weight of rats in their daily routine feed. The hyperlipidemic rats were administered with aqueous stevia extract at different dose levels (200, 300, 400 and 500 ppm/kg b.w.) for 8 weeks; the control rats were fed basal diet during this period. Ethical approval for the current research was obtained from Institutional Review Board Faculty of Science & Technology Government College University, Faisalabad, Pakistan.

RESULTS:

Stevia aqueous extract decreased the body weight gain by lowering the feed intake of hyperlipidemic rats. Furthermore, administration of stevia extract at different levels significantly (P < 0.05) lowered the TC (125.22 ± 5.91 to 110.56 ± 5.81 mg/dL), TG (102.13 ± 6.89 to 98.62 ± 7.22 mg/dL), LDL (33.02 ± 4.79 to 22.77 ± 4.36 mg/dL), VLDL (21.22 ± 5.79 to 19.33 ± 5.95 mg/dL) levels and LDL/HDL ratios (0.83 ± 1.22 to 0.54 ± 1.66 mg/dL) from H1 to H4. Conversely, it improved the HDL (39.76 ± 4.34 to l42.02 ± 4.39 mg/dL) level in hyperlipidemic rats compared with untreated rats after eight weeks study period.

CONCLUSION:

It is concluded that aqueous extract of stevia has anti-hyperlipidemic effects in albino rats, and therefore could be a promising nutraceutical therapy for the management of hyperlipidemia and its associated complications.

KEYWORDS:

Stevia rebaudiana Bertoni-Stevioside-hyperlipidemia

PMID:
30053819
PMCID:
PMC6064095
DOI:
10.1186/s12944-018-0810-9
[Indexed for MEDLINE]
Free PMC Article

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