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Asian Pac J Cancer Prev. 2018 Jul 27;19(7):1927-1933.

Levels of Pro and Anti-inflammatory Citokynes and C-Reactive Protein in Patients with Chronic Periodontitis Submitted to Nonsurgical Periodontal Treatment

Author information

1
University of Uberaba, Uberaba, MG, Brazil.Email: sanivia.pereira@uniube.br

Abstract

AIM:

to compare the levels of IFN-γ, TGF-β and C-reactive protein (CRP) in healthy patients (HP) and chronic periodontitis patients (CP) before and seven days after the last session of Non-Surgical Periodontal Treatment (NSPT).

MATERIALS AND METHODS:

40 subjects were divided into two groups: healthy (n= 20), and with chronic periodontitis (n = 20). Serum and gingival crevicular fluid (GCF) were collected from each patient and quantified for IFN-γ, TGF-β and CRP using the enzyme-linked immunosorbent assay (ELISA).

RESULTS:

IFN-γ was found to be higher in the GCF of the CP group before NSPT in relation to the HP group (p<0.05), and it had significant higher levels after seven days of NSPT (p<0.05). The levels of TGF-β in the GCF of CP patients before NSPT were significantly higher when compared to HP (p<0.05), but they decreased after seven days of NSPT (p>0.05). Serum CRP levels did not show statistical difference between CP and HP before or after NSPT.

CONCLUSION:

Therefore, our results demonstrated for the first time that NSPT causes early exacerbation of the immune response at the local level represented by increased levels of IFN-γ and decreased levels of TGF-β in the gingival crevicular fluid after seven days of treatment.

KEYWORDS:

C-reactive protein; cytokines; immune system; inflammation; periodontitis

PMID:
30051674
PMCID:
PMC6165634
DOI:
10.22034/APJCP.2018.19.7.1927
[Indexed for MEDLINE]
Free PMC Article

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