Format

Send to

Choose Destination
Head Neck. 2018 Oct;40(10):2280-2287. doi: 10.1002/hed.25337. Epub 2018 Jul 26.

Pretreatment metabolic tumor volume as a prognostic factor in HPV-associated oropharyngeal cancer in the context of AJCC 8th edition staging.

Author information

1
Washington University School of Medicine, Department of Radiation Oncology, St Louis, MO.
2
Mayo Clinic, Department of Biomedical Statistics and Informatics Scottsdale, AZ.
3
St Louis University School of Medicine, St Louis, MO.
4
Keck School of Medicine of University of Southern California, Department of Radiation Oncology, Los Angeles, CA.
5
Washington University School of Medicine, Mallinckrodt Institute of Radiology Division of Nuclear Medicine, St Louis, MO.
6
American Board of Otolaryngology, Houston, TX.
7
Washington University School of Medicine, Department of Internal Medicine, Division of Oncology, St Louis, MO.

Abstract

BACKGROUND:

This study evaluates the prognostic significance of 18 F-fluorodeoxyglucose-positron emission tomography ([F-18]FDG-PET)-derived metabolic tumor volume (MTV) in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinomas (OPSCCs) in the context of AJCC 8th edition staging.

METHODS:

We performed a retrospective study of HPV-associated OPSCCs treated with postoperative or definitive radiation. The prognostic significance of pretreatment MTV for freedom from recurrence (FFR), freedom from distant metastasis (FFDM), and overall survival (OS) was determined using Kaplan-Meier analysis. Multivariate analysis (MVA) was performed using Cox regression.

RESULTS:

In this 153-patient cohort, stratifying by the optimum MTV (24 cm3 ) was prognostic for FFR (P = .0002), FFDM (P = .001), and OS (P < .0001). Metabolic tumor volume (MTV) was prognostic of FFR in AJCC 8th edition stage I/II (P = .03), and stage III patients (P = .04). On multivariate analysis only MTV was a significant factor for OS.

CONCLUSION:

Metabolic tumor volume (MTV) is a significant prognostic factor in HPV-associated OPSCCs, independent of AJCC 8th edition stage.

KEYWORDS:

human papillomavirus (HPV); metabolic tumor volume; oropharyngeal cancer; positron emission tomography; prognostic markers

PMID:
30051553
DOI:
10.1002/hed.25337

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center