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Nat Cell Biol. 2018 Aug;20(8):888-899. doi: 10.1038/s41556-018-0142-z. Epub 2018 Jul 26.

YAP/TAZ upstream signals and downstream responses.

Author information

1
Department of Molecular Medicine (DMM), University of Padua School of Medicine, Padua, Italy.
2
Department of Molecular Medicine (DMM), University of Padua School of Medicine, Padua, Italy. piccolo@bio.unipd.it.
3
IFOM-The FIRC Institute of Molecular Oncology, Milan, Italy. piccolo@bio.unipd.it.

Abstract

Cell behaviour is strongly influenced by physical, mechanical contacts between cells and their extracellular matrix. We review how the transcriptional regulators YAP and TAZ integrate mechanical cues with the response to soluble signals and metabolic pathways to control multiple aspects of cell behaviour, including proliferation, cell plasticity and stemness essential for tissue regeneration. Corruption of cell-environment interplay leads to aberrant YAP and TAZ activation that is instrumental for multiple diseases, including cancer.

PMID:
30050119
PMCID:
PMC6186418
DOI:
10.1038/s41556-018-0142-z
[Indexed for MEDLINE]
Free PMC Article

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