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Blood Purif. 2018;46(4):301-308. doi: 10.1159/000490612. Epub 2018 Jul 26.

Microbiota Quality and Mitochondrial Activity Link with Occurrence of Muscle Cramps in Hemodialysis Patients using Citrate Dialysate: A Pilot Study.

Author information

1
ECHO, Dialysis Department, Centre Hospitalier Bretagne-Atlantique, Vannes, France.
2
Cochin Institute - INSERM U1016, University Paris Descartes, Development, Reproduction and Cancer, Cochin Hospital, Paris, France.
3
University of Liège, Centre for Oxygen, Research and Development (CORD), Liège, Belgium.
4
Pierre Beregovoy Hospital Center, Nevers, France.

Abstract

BACKGROUND/AIMS:

Hemodialysis-associated muscle cramp (HAMC) is a common complication under citrate dialysate (CD) occurring in 30% of cases. Our objectives were to assess the gut microbiota quality, mitochondrial activity, and to investigate their possible relationship with HAMC.

METHODS:

Ten end-stage renal disease patients (78.9 ± 2.1 years) treated by hemodialysis (HD) with CD were enrolled and then classified according to the frequency of HAMCs: "frequent HAMCs group" (n = 5) and "absence of HAMCs group" (n = 5). Gut microbiota quality, mitochondrial activity, and some markers of oxidative stress (OS) were investigated.

RESULTS:

In patients with cramps, gut microbiota diversity seemed lower and some genera including Helicobacter, Lachnospira, Roseburia, and Haemophilus seemed over-expressed, a significant increase of citratemia and significant lowering mitochondrial function were observed. No difference was observed on the OS markers.

CONCLUSION:

This first clinical study revealed a possible dysbiosis of microbiota and a mitochondrial dysfunction into HD patients with cramps under CD compared to patients without cramp.

KEYWORDS:

Citrate dialysate; Hemodialysis; Hypercitratemia; Microbiota; Mitochondria; Muscle cramps

PMID:
30048977
DOI:
10.1159/000490612
[Indexed for MEDLINE]

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