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Epilepsy Res. 2018 Sep;145:185-197. doi: 10.1016/j.eplepsyres.2018.07.005. Epub 2018 Jul 17.

Co-morbid sleep disorders and epilepsy: A narrative review and case examples.

Author information

1
Department of Neurology, Brigham and Women's Hospital, Boston, MA, United States.
2
Center for Sleep Medicine, Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, United States.
3
Department of Neurology, Brigham and Women's Hospital, Boston, MA, United States. Electronic address: mpavlova@bwh.harvard.edu.

Abstract

Co-morbid sleep disorders, including sleep apnea, insomnia, restless legs syndrome, and the parasomnias, occur frequently in people with epilepsy. This article reviews the cardinal presenting symptoms and diagnostic features of each of these disorders to enable epileptologists to readily screen and identify sleep co-morbidities in their patients. It summarizes current evidence concerning the reciprocal relationship between sleep disturbances and epilepsy and available treatment options for common sleep disorders in people with epilepsy. Several illustrative cases demonstrate the practical consequences of co-morbid sleep disorders in epilepsy patients and suggest diagnostic and treatment approaches that may improve daytime functioning, alertness, quality of life, and seizure burden.

KEYWORDS:

Co-morbid sleep disorders; Insomnia; Parasomnias; Restless legs syndrome; Sleep apnea

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