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Med Sci Monit. 2018 Jul 26;24:5192-5199. doi: 10.12659/MSM.908021.

Astragalus Polysaccharide Protects Neurons and Stabilizes Mitochondrial in a Mouse Model of Parkinson Disease.

Liu H1,2,3, Chen S4, Guo C2,5, Tang W6, Liu W6, Liu Y1.

Author information

1
Department of Neurology, Qilu Hospital of Shandong University, Jinan, Shandong, China (mainland).
2
Department of Neurology, People's Hospital of Liaocheng Affiliated to Taishan Medical College, Liaocheng, Shandong, China (mainland).
3
Department of Neurology, First Hospital of Liaocheng University, Liaocheng, Shandong, China (mainland).
4
Department of Neurosurgery, Qilu Hospital of Shandong University, Jinan, Shandong, China (mainland).
5
Department of Neurology, First Hospital of Liaocheng University, Liaocheng, Shandong.
6
Department of Central Laboratory, People's Hospital of Liaocheng Affiliated to Taishan Medical College, Liaocheng, Shandong, China (mainland).

Abstract

BACKGROUND Astragalus polysaccharides (APS) have a very good therapeutic effect in the treatment of neurodegenerative diseases and nerve injury disease. However, research on Parkinson disease (PD) treatment with APS is lacking. MATERIAL AND METHODS The present study was designed to explore the effects of APS on the protection of neurons and mitochondrial in a mouse model of PD using behavioral experiments, and observations of mitochondrial structure and transmembrane potential. RESULTS It was shown that APS could attenuate 1-methyl-4-pheyl-1,2,3,6-tetrahydropyridine (MPTP)-induced motor dysfunction (P<0.01), increase the proportion of TH-positive cells (P<0.01), reverse MPTP-induced mitochondrial structural damage, and reduce MPTP-induced high levels of reactive oxygen species (ROS) and increase MPTP-induced decrease in mitochondrial membrane potential. In addition, APS also decreased the bax/bcl2 ratio, and cytochrome-c and caspase-3 protein content (P<0.01) in substantia nigra in our mouse PD model. CONCLUSIONS APS provided a protective effect on neurons and mitochondrial in a mouse PD model.

PMID:
30048421
PMCID:
PMC6074062
DOI:
10.12659/MSM.908021
[Indexed for MEDLINE]
Free PMC Article

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