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Sci Rep. 2018 Jul 25;8(1):11194. doi: 10.1038/s41598-018-29515-2.

Epidemiology of intussusception before and after rotavirus vaccine introduction in Fiji.

Author information

1
Ministry of Health and Medical Services, Suva, Fiji.
2
Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
3
Fiji Health Sector Support Program, Suva, Fiji.
4
Telethon Kids Institute, Perth, Western Australia, Australia.
5
Menzies School of Health Research, Darwin, Northern Territory, Australia.
6
London School of Hygiene and Tropical Medicine, London, UK.
7
Fiji National University, Suva, Fiji.
8
Centre for International Child Health, Dept. of Paediatrics, The University of Melbourne, Melbourne, Victoria, Australia.
9
Murdoch Children's Research Institute, Melbourne, Victoria, Australia. fmruss@unimelb.edu.au.
10
Centre for International Child Health, Dept. of Paediatrics, The University of Melbourne, Melbourne, Victoria, Australia. fmruss@unimelb.edu.au.

Abstract

In 2012, Fiji introduced rotavirus vaccine (Rotarix, GSK) into the national immunisation schedule. We describe the intussusception epidemiology prior to rotavirus vaccine, temporal association of intussusception cases to administration of rotavirus vaccine, and estimate the additional number of intussusception cases that may be associated with rotavirus vaccine. A retrospective review of intussusception cases for children aged <24 months old was undertaken between January 2007 and October 2012 pre-vaccine. All admissions and deaths with a discharge diagnosis of intussusception, bowel obstruction, paralytic ileus, or intussusception ICD10-AM codes were extracted from national databases and hospital records. Nationwide active intussusception surveillance was established for three years post-vaccine (2013-2015). There were 24 definite intussusception cases in the pre-rotavirus vaccine period, 96% were confirmed by surgery. The median age was 6.5 months. The incidence rate was 22.2 (95% CI: 13.9-33.7) per 100,000 infants. There were no deaths. Active surveillance identified 25 definite intussusception cases, 96% of which were among children who were age-eligible for rotavirus vaccine. None were potentially vaccine related. We estimated one to five additional  cases of intussusception every five years. The incidence of intussusception pre-rotavirus vaccine in Fiji is low. Intussusception associated with rotavirus vaccine is likely a rare event in Fiji.

PMID:
30046133
PMCID:
PMC6060119
DOI:
10.1038/s41598-018-29515-2
[Indexed for MEDLINE]
Free PMC Article

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