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Nature. 2018 Jul;559(7715):498-506. doi: 10.1038/s41586-018-0327-4. Epub 2018 Jul 25.

Challenges and recent progress in drug discovery for tropical diseases.

Author information

1
Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK.
2
Medicines Monitoring Unit (MEMO), Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.
3
Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK. i.h.gilbert@dundee.ac.uk.

Abstract

Infectious tropical diseases have a huge effect in terms of mortality and morbidity, and impose a heavy economic burden on affected countries. These diseases predominantly affect the world's poorest people. Currently available drugs are inadequate for the majority of these diseases, and there is an urgent need for new treatments. This Review discusses some of the challenges involved in developing new drugs to treat these diseases and highlights recent progress. While there have been notable successes, there is still a long way to go.

PMID:
30046073
PMCID:
PMC6129172
DOI:
10.1038/s41586-018-0327-4
[Indexed for MEDLINE]
Free PMC Article

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