Format

Send to

Choose Destination
Nat Rev Neurosci. 2018 Sep;19(9):552-565. doi: 10.1038/s41583-018-0041-0.

Enteric nervous system development: what could possibly go wrong?

Author information

1
Department of Pediatrics, Columbia University, New York, NY, USA.
2
Department of Pathology and Cell Biology, Columbia University, New York, NY, USA. mdg4@cumc.columbia.edu.

Abstract

The gastrointestinal tract contains its own set of intrinsic neuroglial circuits - the enteric nervous system (ENS) - which detects and responds to diverse signals from the environment. Here, we address recent advances in the understanding of ENS development, including how neural-crest-derived progenitors migrate into and colonize the bowel, the formation of ganglionated plexuses and the molecular mechanisms of enteric neuronal and glial diversification. Modern lineage tracing and transcription-profiling technologies have produced observations that simultaneously challenge and affirm long-held beliefs about ENS development. We review many genetic and environmental factors that can alter ENS development and exert long-lasting effects on gastrointestinal function, and discuss how developmental defects in the ENS might account for some of the large burden of digestive disease.

PMID:
30046054
PMCID:
PMC6261281
DOI:
10.1038/s41583-018-0041-0
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center