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J Cell Commun Signal. 2018 Dec;12(4):731-735. doi: 10.1007/s12079-018-0482-2. Epub 2018 Jul 24.

The 5-Hydroxytryptamine signaling map: an overview of serotonin-serotonin receptor mediated signaling network.

Author information

1
Institute of Bioinformatics, International Tech Park, Bangalore, 560066, India.
2
Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, 575018, India.
3
Manipal Academy of Higher Education (MAHE), Manipal, 576104, India.
4
Hans Berger, Department of Neurology, Universitätsklinikum Jena, Jena, Germany.
5
Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam, 690525, India.
6
Molecular Genetics Laboratory, Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, 560029, India.
7
Institute of Bioinformatics, International Tech Park, Bangalore, 560066, India. keshav@yenepoya.edu.in.
8
Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, 575018, India. keshav@yenepoya.edu.in.

Abstract

The monoamine neurotransmitter, 5-Hydroxytryptamine or serotonin, is derived from tryptophan and synthesized both centrally and systemically. Fourteen structurally and functionally distinct receptor subtypes have been identified for serotonin, each of which mediates the neurotransmitter's effects through a range of downstream signaling molecules and effectors. Although it is most frequently described for its role in the etiology of neuropsychiatric and mood disorders, serotonin has been implicated in a slew of fundamental physiological processes, including apoptosis, mitochondrial biogenesis, cell proliferation and migration. Its roles as the neurotransmitter have also emerged in pathogenic conditions ranging from anorexia nervosa to cancer. This has necessitated the understanding of the signaling mechanisms underlying the serotonergic system, which led us to construct a consolidative pathway map, which will provide as a resource for future biomedical investigation on this pathway. Using a set of stringent NetPath annotation criteria, we manually curated molecular reactions associated with serotonin and its receptors from publicly available literature; the reaction categories included molecular associations, activation/inhibition, post-translation modification, transport, and gene regulation at transcription and translational level. We identified 90 molecules in serotonin-serotonin receptor pathway. We submitted the curated data to NetPath, a publicly available database of human signaling pathways, in order to enable the wider scientific community to readily access data and contribute further to this pathway.

KEYWORDS:

Gene expression; NetSlim; Post-translational modification; Protein-protein interaction; Serotonylation; Sleep

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