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Kaohsiung J Med Sci. 2018 Aug;34(8):423-427. doi: 10.1016/j.kjms.2018.03.004. Epub 2018 Apr 5.

Vitamin D: And its role in breast cancer.

Author information

1
Obstetrics and Gynecology, Hospital Clínico Universitario, San Carlos, Madrid, Spain.
2
Laboratory of Medicine, Hospital Clínico Universitario, San Carlos, Madrid, Spain.
3
Department of Medicine, Complutense University, Madrid, Spain.
4
Department of Medicine, Complutense University, Madrid, Spain. Electronic address: lcollado@ucm.es.

Abstract

Vitamin D is a fat soluble vitamin that plays a role in calcium and phosphorus homeostasis. Recently, extensive research on its extraskeletal actions has linked vitamin D deficiency to an increased risk of infection, diabetes mellitus types 1 and 2, cardiovascular disease, obesity, asthma, inflammatory bowel disease, colon, breast, prostate and ovarian cancer and some neurological diseases. There are various mechanisms by which vitamin D influences the natural history of cancer. These include the role of vitamin D in the induction of apoptosis, stimulation of cell differentiation, anti-inflammatory and antiproliferative effects and inhibition of angiogenesis, invasion and metastasis. The aim of this review is to clarify the true role of vitamin D in the onset of breast cancer and evolution of the disease after treatment. A further aim is to suggest new research directions to identify indications and requirements for vitamin D supplementation in patients with breast cancer.

KEYWORDS:

1,25-dihydroxyvitamin D; 25-hydroxyvitamin D; Breast cancer; Vitamin D

PMID:
30041759
DOI:
10.1016/j.kjms.2018.03.004
[Indexed for MEDLINE]
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