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Aging Male. 2019 Mar;22(1):68-73. doi: 10.1080/13685538.2018.1481940. Epub 2018 Jul 24.

Testosterone level in aging male with different glucose tolerance state and its association with osteocalcin.

Author information

1
a Department of Geriatric Endocrinology, Nanlou Division , Chinese PLA General Hospital, National Clinical Research Center for Geriatric Diseases , Beijing , China.

Abstract

OBJECTIVE:

To investigate the relationship of testosterone and different glucose tolerance state, and its association with osteocalcin.

METHODS:

A cross-sectional study was conducted of 1176 males aged 60-97 years who were arranged for an annual regular checkup from March to May 2012 in Chinese PLA general hospital in Beijing.

RESULTS:

Individuals categorized as having prediabetes or diabetes were more likely to have lower osteocalcin, testosterone, and SHBG levels compared to those with normal glucose tolerance (p < .05 in males). In aging males, after adjusting for age, the negative association between osteocalcin and BMI, waist circumference, FPG, 2hPBG, or TG were significant. And serum TT was negatively associated with BMI, waist circumference, FPG, 2hPBG, or TG independent of age, ALP, Ca, P, VitD, and PTH.

CONCLUSIONS:

It showed that serum osteocalcin and TT were closely related with BMI, blood glucose, and TG, which supported the hypothesis that regulation of bone remodeling, energy metabolism, and reproduction are linked.

KEYWORDS:

Testosterone; aging male; blood glucose; diabetes; osteocalcin

PMID:
30039993
DOI:
10.1080/13685538.2018.1481940
[Indexed for MEDLINE]

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