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Eur J Clin Microbiol Infect Dis. 2018 Oct;37(10):1973-1982. doi: 10.1007/s10096-018-3333-4. Epub 2018 Jul 23.

Etiologies, risk factors, and outcomes of bacterial cholangitis after living donor liver transplantation.

Author information

1
Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
2
Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan. shintaro@kuhp.kyoto-u.ac.jp.
3
Department of Infection Control and Prevention, Kyoto University Hospital, Kyoto, Japan.
4
Department of Biomedical Statistics and Bioinformatics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
5
Department of Surgery, Kobe City Nishi-Kobe Medical Center, Kobe, Japan.

Abstract

The interpretation of bacterial cholangitis after liver transplantation (LT) remains vague, because the presence of bacteria in bile, namely bacteriobilia, does not necessarily indicate an active infection. We investigated the association between post-LT bacterial cholangitis and a variety of short- and long-term outcomes. Two-hundred-seventy-four primary adult-to-adult living donor LT recipients from 2008 to 2016 were divided into three groups according the presence or absence of bacteriobilia and clinical symptoms: (1) no bacteriobilia (N group), (2) asymptomatic bacteriobilia (B group), and (3) cholangitis (C group). The number of patients was by group: N, 161; B, 64; and C, 49. Donor age ≥ 45 years (p = 0.012), choledochojejunostomy (p < 0.001), and post-LT portal hypertension (p = 0.023) were independent risk factors for developing cholangitis. Survival analysis revealed that the C group had significantly worse short- and long-term graft survival. The C group was associated with an increased incidence of early graft loss (EGL) (p < 0.001). While the frequency of readmission for recurrent cholangitis was significantly higher in both the B and C groups (p < 0.001), late graft loss (LGL) due to chronic cholangitis was only commonly observed in the C group (p = 0.002). Post-LT cholangitis could result in not only EGL but also chronic cholangitis and associated LGL.

KEYWORDS:

Bacterial cholangitis; Bacteriobilia; Graft loss; Living donor liver transplantation

PMID:
30039291
DOI:
10.1007/s10096-018-3333-4
[Indexed for MEDLINE]

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