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Mult Scler J Exp Transl Clin. 2018 Jul 17;4(3):2055217318787829. doi: 10.1177/2055217318787829. eCollection 2018 Jul-Sep.

MOG-IgG-associated disease has a stereotypical clinical course, asymptomatic visual impairment and good treatment response.

Author information

1
Department of Neurology, Nitte University, India.
2
Department of Neurology, Tohoku University Graduate School of Medicine, Japan.

Abstract

Objectives:

We investigated the clinical characteristics and treatment response in myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-associated disease and looked for evidence of subclinical disease.

Methods:

We prospectively evaluated the frequency and pattern of relapse, tested afferent visual function and monitored treatment response in 42 south Asian patients from a single centre.

Results:

Eighteen patients (42.9%) had monophasic and 24 (57.1%) a relapsing course. Disease duration was longer (P<0.02) in those with a relapsing course. Median time to the second attack was prolonged (P<0.04) in patients with recurrent transverse myelitis when compared with neuromyelitis optica spectrum disorder and recurrent optic neuritis. Thirteen out of 17 patients (76.5%) initially presenting with optic neuritis developed recurrent optic neuritis later. After the first attack of transverse myelitis, 17 out of 22 (77.3%) had disease confined to the spinal cord. Optical coherence tomography detected peripapillary retinal nerve fibre layer thickness (P<0.05) and macular ganglion cell complex volume (P<0.005) abnormalities in seven out of 10 (70.0%) patients without clinical optic neuritis. Immunosuppressants induced remission in 17 out of 22 (77.3%) patients during a median follow-up of 48 months and the median Expanded Disability Status Score was 1 (range 1-10).

Conclusion:

Our study highlighted the tendency for stereotypical attacks in MOG-IgG-associated disease, heterogeneity in clinical course among subtypes, subclinical visual impairment and the need for early and sustained immunosuppressive therapy.

KEYWORDS:

Demyelinating disorders; South India; anti-MOG-IgG; disease heterogeneity; subclinical visual loss

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