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Paediatr Child Health. 2018 Jul;23(4):245-246. doi: 10.1093/pch/pxy011. Epub 2018 Mar 10.

Fever prophylaxis can reduce vaccine responses: A caution.

Author information

1
Vaccine Evaluation Center, BC Children's Hospital Research Institute, Vancouver, British Columbia.
2
Canadian Association for Immunization Research and Evaluation, Vancouver, British Columbia.
3
McGill Vaccine Studies Center, McGill University Health Center, Montreal, Qu├ębec.

Abstract

Prophylactic administration of antipyretic/analgesic drugs, started at the time of immunization and repeated 6 and 12 hours later, is sometimes undertaken to reduce postimmunization fever and irritability in infants. Two recent studies showed that such prophylaxis can reduce immune responses to some infant vaccines, warranting judicious use. In contrast, implementing treatment 6 hours or more after immunization had no effect on vaccine responses and would reduce drug exposure of asymptomatic infants.

KEYWORDS:

Acetaminophen; Childhood; Fever prophylaxis; Ibuprophen; Immunization; Vaccine immunogenicity

PMID:
30038529
PMCID:
PMC6007407
[Available on 2019-07-01]
DOI:
10.1093/pch/pxy011

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