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Neuroimage Clin. 2018 Apr 24;19:271-278. doi: 10.1016/j.nicl.2018.04.024. eCollection 2018.

Radiomics analysis allows for precise prediction of epilepsy in patients with low-grade gliomas.

Author information

1
CAS Key Laboratory of Molecular Imaging, Institute of Automation, Beijing 100190, China.
2
Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China; Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China.
3
School of Mechanical, Electrical & Information Engineering, Shandong University, Weihai, Shandong Province 264209, China.
4
Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.
5
Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China; Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China. Electronic address: taojiang1964@163.com.
6
CAS Key Laboratory of Molecular Imaging, Institute of Automation, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100080, China. Electronic address: jie.tian@ia.ac.cn.

Abstract

Purpose:

To investigate the association between imaging features and low-grade gliomas (LGG) related epilepsy, and to propose a radiomics-based model for the prediction of LGG-associated epilepsy.

Methods:

This retrospective study consecutively enrolled 286 patients with LGGs (194 in the primary cohort and 92 in the validation cohort). T2-weighted MR images (T2WI) were used to characterize risk factors for LGG-related epilepsy: Tumor location features and 3-D imaging features were determined, following which the interactions between these two kinds of features were analyzed. Elastic net was applied to generate a radiomics signature combining key imaging features associated with the LGG-related epilepsy with the primary cohort, and then a nomogram incorporating radiomics signature and clinical characteristics was developed. The radiomics signature and nomogram were validated in the validation cohort.

Results:

A total of 475 features associated with LGG-related epilepsy were obtained for each patient. A radiomics signature with eleven selected features allowed for discriminating patients with epilepsy or not was detected, which performed better than location and 3-D imaging features. The nomogram incorporating radiomics signature and clinical characteristics achieved a high degree of discrimination with area under receiver operating characteristic (ROC) curve (AUC) at 0.8769 in the primary cohort and 0.8152 in the validation cohort. The nomogram also allowed for good calibration in the primary cohort.

Conclusion:

We developed and validated an effective prediction model for LGG-related epilepsy. Our results suggested that radiomics analysis may enable more precise and individualized prediction of LGG-related epilepsy.

KEYWORDS:

Elastic net; Epilepsy; Low grade gliomas; Radiomics; T2WI

PMID:
30035021
PMCID:
PMC6051495
DOI:
10.1016/j.nicl.2018.04.024
[Indexed for MEDLINE]
Free PMC Article

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