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Curr Mol Med. 2018;18(3):160-165. doi: 10.2174/1566524018666180720165055.

Oxidative Stress in Cerebral Small Vessel Disease Dizziness Patients, Basally and After Polyphenol Compound Supplementation.

Author information

1
Department of Experimental and Clinical Medicine, Neurological Clinic, Pisa University, Pisa, Italy.
2
Department of Medical and Surgical Pathology, Otorhinolaryngology Section, Pisa University, Pisa, Italy.

Abstract

BACKGROUND:

Leukoaraiosis (LA) is a common radiological finding in elderly, frequently associated with several clinical disorders, including unexplained dizziness. The pathogenesis of LA is multifactorial, with a dysfunction of cerebral microcirculation resulting in chronic hypoperfusion and tissue loss, with oxidative stress involved in this cascade.

OBJECTIVE:

The aim of this study was to analyse some oxidative stress biomarkers in a cohort of LA patients.

METHOD:

Fifty-five consecutive patients (33 males, median age 75 years) with LA were recruited. In a subgroup of 33 patients with LA and unexplained dizziness, we have then performed an open study to evaluate if 60-day supplementation with a polyphenol compound may modify these biomarkers and influence quality of life, analysed with the Dizziness Handicap Inventory (DHI) scale.

RESULTS:

At baseline, blood oxidative stress parameters values were outside normal ranges and compared to matched healthy controls. After the two months supplementation, we observed a significant decrement of advanced oxidation protein products values and a significant improvement of DHI.

CONCLUSION:

Oxidative stress biomarkers may be useful to detect redox imbalance in LA and to provide non-invasive tools to monitor disease status and response to therapy.

KEYWORDS:

DHI; Leukoaraiosis; cerebral small vessel disease; dizziness; oxidative stress; polyphenols.

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