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Curr Mol Med. 2018;18(3):160-165. doi: 10.2174/1566524018666180720165055.

Oxidative Stress in Cerebral Small Vessel Disease Dizziness Patients, Basally and After Polyphenol Compound Supplementation.

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Department of Experimental and Clinical Medicine, Neurological Clinic, Pisa University, Pisa, Italy.
Department of Medical and Surgical Pathology, Otorhinolaryngology Section, Pisa University, Pisa, Italy.



Leukoaraiosis (LA) is a common radiological finding in elderly, frequently associated with several clinical disorders, including unexplained dizziness. The pathogenesis of LA is multifactorial, with a dysfunction of cerebral microcirculation resulting in chronic hypoperfusion and tissue loss, with oxidative stress involved in this cascade.


The aim of this study was to analyse some oxidative stress biomarkers in a cohort of LA patients.


Fifty-five consecutive patients (33 males, median age 75 years) with LA were recruited. In a subgroup of 33 patients with LA and unexplained dizziness, we have then performed an open study to evaluate if 60-day supplementation with a polyphenol compound may modify these biomarkers and influence quality of life, analysed with the Dizziness Handicap Inventory (DHI) scale.


At baseline, blood oxidative stress parameters values were outside normal ranges and compared to matched healthy controls. After the two months supplementation, we observed a significant decrement of advanced oxidation protein products values and a significant improvement of DHI.


Oxidative stress biomarkers may be useful to detect redox imbalance in LA and to provide non-invasive tools to monitor disease status and response to therapy.


DHI; Leukoaraiosis; cerebral small vessel disease; dizziness; oxidative stress; polyphenols.

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