Send to

Choose Destination
Int J Med Inform. 2018 Sep;117:112-124. doi: 10.1016/j.ijmedinf.2018.06.009. Epub 2018 Jun 27.

A new computational intelligence approach to detect autistic features for autism screening.

Author information

Health and Human Sciences, Department of Psychology, University of Huddersfield, Huddersfield, UK. Electronic address:
Canadian University Dubai, Dubai, United Arab Emirates. Electronic address:
College of Computer Science and Information System, Najran University, Najran, Saudi Arabia. Electronic address:


Autism Spectrum Disorder (ASD) is one of the fastest growing developmental disability diagnosis. General practitioners (GPs) and family physicians are typically the first point of contact for patients or family members concerned with ASD traits observed in themselves or their family member. Unfortunately, some families and adult patients are unaware of ASD traits that may be exhibited and as a result do not seek out necessary diagnostic services or contact their GP. Therefore, providing a quick, accessible, and simple tool utilizing items related to ASD to these families may increase the likelihood they will seek professional assessment and is vital to the early detection and treatment of ASD. This study aims at identifying fewer, albeit influential, features in common ASD screening methods in order to achieve efficient screening as demands on evaluating the items' influences on ASD within existing tools is urgent. To achieve this aim, a computational intelligence method called Variable Analysis (Va) is proposed that considers feature-to-class correlations and reduces feature-to-feature correlations. The results of the Va have been verified using two machine learning algorithms by deriving automated classification systems with respect to specificity, sensitivity, positive predictive values (PPVs), negative predictive values (NPVs), and predictive accuracy. Experimental results using cases and controls related to items in three common screening methods, along with features related to individuals, have been analysed and compared with results obtained from other common filtering methods. The results exhibited that Va was able to derive fewer numbers of features from adult, adolescent, and child screening methods yet maintained competitive predictive accuracy, sensitivity, and specificity rates.


Accuracy; Autism Spectrum Disorder; Behaviour science; Classifiers; Computational intelligence; Data mining; Feature analysis; Machine learning; Sensitivity; Specificity

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center