Format

Send to

Choose Destination
Semin Cell Dev Biol. 2018 Jul 27. pii: S1084-9521(17)30596-7. doi: 10.1016/j.semcdb.2018.07.022. [Epub ahead of print]

The three-dimensional organization of the genome in cellular senescence and age-associated diseases.

Author information

1
Center for Computational Molecular Biology, Brown University, Providence, RI, United States.
2
Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, United States.
3
Center for Computational Molecular Biology, Brown University, Providence, RI, United States; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, United States. Electronic address: nicola_neretti@brown.edu.

Abstract

Recent advances in genomics and imaging technologies have increased our ability to interrogate the 3D conformation of chromosomes and to better understand principles of organization and dynamics, as well as how their alteration can lead to disease. In this review we describe how these technologies have shed new light into the role of the 3D organization of the genome in defining cellular states in aging and age-associated diseases. We compare the genomic organization in cellular senescence and cancer, discuss the role of the lamina in maintaining the structural and functional integrity of the genome, and we highlight the recent findings on how this organization breaks down in disease states.

KEYWORDS:

Aging; Cancer; Cytoplasmic DNA; Hi-C; Inflammation; Senescence

PMID:
30031215
DOI:
10.1016/j.semcdb.2018.07.022
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center