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Cancer Causes Control. 2018 Sep;29(9):833-844. doi: 10.1007/s10552-018-1059-3. Epub 2018 Jul 20.

Incidence of primary liver cancer in American Indians and Alaska Natives, US, 1999-2009.

Author information

1
Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, 1720 Louisiana Blvd NE, Suite 208, Albuquerque, NM, 87110, USA. mzv3@cdc.gov.
2
Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, 1720 Louisiana Blvd NE, Suite 208, Albuquerque, NM, 87110, USA.
3
Northwest Portland Area Indian Health Board, Portland, OR, USA.
4
Cedars-Sinai Medical Center, Department of Surgery, Los Angeles, CA, USA.
5
Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA, USA.
6
New Mexico Tumor Registry, University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA.

Abstract

PURPOSE:

To evaluate liver cancer incidence rates and risk factor correlations in non-Hispanic AI/AN populations for the years 1999-2009.

METHODS:

We linked data from 51 central cancer registries with the Indian Health Service patient registration databases to improve identification of the AI/AN population. Analyses were restricted to non-Hispanic persons living in Contract Health Service Delivery Area counties. We compared age-adjusted liver cancer incidence rates (per 100,000) for AI/AN to white populations using rate ratios. Annual percent changes (APCs) and trends were estimated using joinpoint regression analyses. We evaluated correlations between regional liver cancer incidence rates and risk factors using Pearson correlation coefficients.

RESULTS:

AI/AN persons had higher liver cancer incidence rates than whites overall (11.5 versus 4.8, RR = 2.4, 95% CI 2.3-2.6). Rate ratios ranged from 1.6 (Southwest) to 3.4 (Northern Plains and Alaska). We observed an increasing trend among AI/AN persons (APC 1999-2009 = 5%). Rates of distant disease were higher in the AI/AN versus white population for all regions except Alaska. Alcohol use (r = 0.84) and obesity (r = 0.79) were correlated with liver cancer incidence by region.

CONCLUSIONS:

Findings highlight disparities in liver cancer incidence between AI/AN and white populations and emphasize opportunities to decrease liver cancer risk factor prevalence.

KEYWORDS:

Alaska Native; American Indian; Cancer incidence; Health disparity; Liver cancer

PMID:
30030669
PMCID:
PMC6108913
[Available on 2019-09-01]
DOI:
10.1007/s10552-018-1059-3
[Indexed for MEDLINE]

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