Format

Send to

Choose Destination
Vitam Horm. 2018;108:385-412. doi: 10.1016/bs.vh.2018.04.001. Epub 2018 Jun 27.

Dehydroepiandrosterone and Addiction.

Author information

1
The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel; The Leslie and Susan Gonda (Goldschmied) Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat Gan, Israel. Electronic address: yadidg@gmail.com.
2
The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.
3
Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Research Unit, Petah Tikva, Israel.
4
Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Research Unit, Petah Tikva, Israel; Geha Mental Health Center, Tel-Aviv University, Tel Aviv, Israel.

Abstract

Drug addiction has a great negative influence on society, both social and economic burden. It was widely thought that addicts could choose to stop using drugs if only they had some self-control and principles. Nowadays, science has changed this view, defining drug addiction as a complex brain disease that affects behavior in many ways, both biological and psychological. Currently there is no ground-breaking reliable treatment for drug addiction. For more than a decade we are researching an alternative approach for intervention with drug craving and relapse to its usage, using DHEA, a well-being and antiaging food supplement. In this chapter we navigate through the significant therapeutic effect of DHEA on the brain circuits that control addiction and on behavioral performance both in animal models and addicts. We suggest that an integrative program of add-on DHEA treatment may further enable to dynamically evaluate the progress of rehabilitation of an individual patient, in a comprehensive assessment. Such a program may boost and support the detoxification and rehabilitation process, and help patients regain a normal life in a shorter amount of time.

KEYWORDS:

Addiction; Cocaine; Craving; Dehydroepiandrosterone; Drug self-administration; Neurogenesis; Neurosteroids; Rehabilitation; Relapse; Reward-related memories

PMID:
30029736
DOI:
10.1016/bs.vh.2018.04.001
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center