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Muscle Nerve. 2018 Oct;58(4):550-558. doi: 10.1002/mus.26189. Epub 2018 Aug 22.

Multiparametric quantitative MRI assessment of thigh muscles in limb-girdle muscular dystrophy 2A and 2B.

Author information

1
Neuroimaging Lab, Scientific Institute, IRCCS E. Medea, Via don L. Monza 20, Bosisio Parini, Italy.
2
Image Sciences Institute, University Medical Center Utrecht and University Utrecht, Utrecht, The Netherlands.
3
NeuroMuscular Unit, Scientific Institute, IRCCS E. Medea, Bosisio Parini, Italy.
4
Neurology Unit, IRCCS Foundation Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
5
Department of Information Engineering, Padova University, Padova, Italy.

Abstract

INTRODUCTION:

The aim of this study was to apply quantitative MRI (qMRI) to assess structural modifications in thigh muscles of subjects with limb girdle muscular dystrophy (LGMD) 2A and 2B with long disease duration.

METHODS:

Eleven LGMD2A, 9 LGMD2B patients and 11 healthy controls underwent a multi-parametric 3T MRI examination of the thigh. The protocol included structural T1-weighted images, DIXON sequences for fat fraction calculation, T2 values quantification and diffusion MRI. Region of interest analysis was performed on 4 different compartments (anterior compartment, posterior compartment, gracilis, sartorius).

RESULTS:

Patients showed high levels of fat infiltration as measured by DIXON sequences. Sartorius and anterior compartment were more infiltrated in LGMD2B than LGMD2A patients. T2 values were mildly reduced in both disorders. Correlations between clinical scores and qMRI were found.

CONCLUSIONS:

qMRI measures may help to quantify muscular degeneration, but careful interpretation is needed when fat infiltration is massive. Muscle Nerve 58: 550-558, 2018.

KEYWORDS:

LGMD2A; LGMD2B; T2 quantification; diffusion MRI; fat fraction; qMRI

PMID:
30028523
DOI:
10.1002/mus.26189

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