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Clin Pharmacol Ther. 2018 Nov;104(5):799-802. doi: 10.1002/cpt.1185. Epub 2018 Sep 4.

Strategies to Reduce Solute Carrier-Mediated Toxicity.

Author information

1
Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
2
Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.

Abstract

Toxicity is among the greatest concerns during clinical use of drugs, and it has been well documented that transporter proteins facilitate such events by regulating drug accumulation. However, an important question is whether strategies could be adopted to diminish such toxicities. Although the field is currently in its infancy, some examples exist demonstrating how mechanistic understanding of the role of transporters in drug disposition can aid in alleviating transporter-mediated toxic effects.

PMID:
30028006
DOI:
10.1002/cpt.1185

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