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Eur J Pediatr. 2018 Oct;177(10):1541-1545. doi: 10.1007/s00431-018-3210-2. Epub 2018 Jul 19.

Prevalence of vitamin D deficiency in cord blood of newborns and the association with maternal vitamin D status.

Author information

1
Department of Pediatrics, Panyananthaphikkhu Chonprathan Medical Center, Srinakharinwirot University, Nonthaburi, 11120, Thailand. ornped@gmail.com.
2
Department of Obstretrics and Gynecology, Panyananthaphikkhu Chonprathan Medical Center, Srinakharinwirot University, Nonthaburi, 11120, Thailand.

Abstract

Vitamin D deficiency is common in Southeast Asia but there are limited data in pregnant women and neonates. This study aimed to determine the prevalence of vitamin D deficiency in cord blood of newborns and the association with maternal vitamin D status. A total of 94 pregnant women and their neonates were included. Clinical data and venous maternal blood for calcium, phosphate, albumin, alkaline phosphatase, magnesium, intact parathyroid hormone (iPTH), and vitamin D (25OHD) were obtained on the day of labor. Cord blood was collected following delivery to evaluate vitamin D status of newborns. Mean serum maternal and cord blood 25OHD levels were 25.42 ± 8.07 and 14.85 ± 5.13 ng/mL. The prevalence of vitamin D deficiency (25OHD < 12 ng/mL) and insufficiency (25OHD 12-20 ng/mL) in cord blood of newborns were 20.2 and 69.1%, respectively. There was a significant correlation between maternal and cord blood vitamin D levels (r = 0.86; P < 0.001). The factors associated with cord blood vitamin D deficiency were low maternal 25OHD level and no vitamin D supplement during pregnancy.

CONCLUSION:

There is a high prevalence of vitamin D deficiency among Thai neonates. Adequate prenatal vitamin D supplementation should be implemented as routine antenatal care. What is Known: • Vitamin D deficiency is prevalent in Southeast Asia. • There are widespread vitamin D deficiency among Thai populations including pregnant women. What is New: • There is a high prevalence of vitamin D deficiency among Thai neonates. • The factors associated with cord blood vitamin D deficiency are low maternal vitamin D level and no vitamin D supplement during pregnancy.

KEYWORDS:

Cord blood; Newborns; Pregnancy; Vitamin D deficiency

PMID:
30027298
DOI:
10.1007/s00431-018-3210-2
[Indexed for MEDLINE]

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