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JAMA. 2018 Aug 7;320(5):499-500. doi: 10.1001/jama.2018.9064.

Probiotics to Prevent Clostridium difficile Infection in Patients Receiving Antibiotics.

Author information

1
Bastyr University Research Institute, Kenmore, Washington.
2
Australian Research Center in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo.
3
Division of Infectious Diseases, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
4
Department of Community Health and Epidemiology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.

Abstract

Clinical Question:

In adults and children prescribed antibiotics, is co-administration of a probiotic associated with a lower risk of symptomatic Clostridium difficile infection without an increase in adverse events?

Bottom Line:

Moderate-quality evidence suggests that probiotics are associated with a lower risk of C difficile infection and very low-quality evidence suggests that probiotics are associated with fewer adverse events vs placebo or no treatment.

PMID:
30027207
DOI:
10.1001/jama.2018.9064
[Indexed for MEDLINE]

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