Send to

Choose Destination
J Cancer. 2018 Jun 15;9(14):2510-2517. doi: 10.7150/jca.25324. eCollection 2018.

Effects of the intestinal microbial metabolite butyrate on the development of colorectal cancer.

Wu X1, Wu Y2, He L3, Wu L4, Wang X3, Liu Z5,6.

Author information

Gannan Medical University, Ganzhou, Jiangxi, China.
The First People's Hospital of Jiashan County, Jiaxing, Zhejiang, China.
The First Affiliated Hospital, Gannan Medical University, Ganzhou, Jiangxi, China.
College of Pharmacy, Gannan Medical University, Ganzhou, Jiangxi, China.
School of Basic Medicine, Gannan Medical University, Ganzhou, Jiangxi, China.
Ganzhou Cancer Precision Engineering Research Center, Ganzhou, Jiangxi, China.


Colorectal cancer (CRC) is one of the major health threats in developed countries. Changes in dietary components, such as more protein and lipid intake, can increase the risk of CRC. Diet affects CRC in many ways. They regulate the composition and function of gut microbiota, which have an amazing metabolic capacity and can produce short chain fatty acids (SCFAs), such as propionate, acetate, and butyrate. Butyrate is a principal energy source for colonic epithelial cells and plays an important role in maintaining the stability of gut microbiota and the integrity of intestinal epithelium. However, there are few studies reviewing the anti-CRC potentials of butyrate. This review summarizes the recent research progresses in the effect of gut microbiota imbalance and the decrease in intestinal microbial metabolite butyrate caused by unbalanced diet on CRC development, and discusses the mechanisms of butyrate-induced anti-CRC activities, which may guide people to prevent CRC by improving diet structures.


Butyrate; Colorectal cancer; Diet.; Gut microbiota

Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Publication type

Publication type

Supplemental Content

Full text links

Icon for Ivyspring International Publisher Icon for PubMed Central
Loading ...
Support Center