Send to

Choose Destination
Front Neurol. 2018 Jul 5;9:537. doi: 10.3389/fneur.2018.00537. eCollection 2018.

The Treatment of Autism Spectrum Disorder With Auditory Neurofeedback: A Randomized Placebo Controlled Trial Using the Mente Autism Device.

Author information

Neurology, Carrick Institute, Cape Canaveral, FL, United States.
Bedfordshire Centre for Mental Health Research in Association with University of Cambridge, Cambridge, United Kingdom.
Harvard Macy Institute and MGH Institute of Health Professions, Boston, MA, United States.
Bioengineering, Carrick Institute, Cape Canaveral, FL, United States.
Department of Electrical and Computer Engineering, University of Wyoming, Laramie, WY, United States.
Psychiatry, Carrick Institute, Cape Canaveral, FL, United States.
Leeds York Partnership NHS Foundation Trust, Leeds, United Kingdom.
Department of Medical Education, Dubai Health Authority, Dubai, United Arab Emirates.
Department of Primary Health Care, Dubai Medical College, Dubai, United Arab Emirates.
Psychiatry, University of Cambridge, Cambridge, United Kingdom.
Neurology, Plasticity Brain Center, Orlando, FL, United States.


Introduction: Children affected by autism spectrum disorder (ASD) often have impairment of social interaction and demonstrate difficulty with emotional communication, display of posture and facial expression, with recognized relationships between postural control mechanisms and cognitive functions. Beside standard biomedical interventions and psychopharmacological treatments, there is increasing interest in the use of alternative non-invasive treatments such as neurofeedback (NFB) that could potentially modulate brain activity resulting in behavioral modification. Methods: Eighty-three ASD subjects were randomized to an Active group receiving NFB using the Mente device and a Control group using a Sham device. Both groups used the device each morning for 45 minutes over a 12 week home based trial without any other clinical interventions. Pre and Post standard ASD questionnaires, qEEG and posturography were used to measure the effectiveness of the treatment. Results: Thirty-four subjects (17 Active and 17 Control) completed the study. Statistically and substantively significant changes were found in several outcome measures for subjects that received the treatment. Similar changes were not detected in the Control group. Conclusions: Our results show that a short 12 week course of NFB using the Mente Autism device can lead to significant changes in brain activity (qEEG), sensorimotor behavior (posturography), and behavior (standardized questionnaires) in ASD children.


autism spectrum disorder; binaural beats; neurofeedback; posturography; qeeg guided neurofeedback

Supplemental Content

Full text links

Icon for Frontiers Media SA Icon for PubMed Central
Loading ...
Support Center