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  • PMID: 30022652 was deleted because it is a duplicate of PMID: 30562883
J Microbiol Biotechnol. 2018 Nov 28;28(11):1876-1882. doi: 10.4014/jmb.1804.04042.

Design, Synthesis and Evaluation of Pentacyclic Triterpenoids Similar to Glycyrrhetinic Acid Via Combination of Chemical and Microbial Modification as Glycogen Phosphorylases Inhibitor.

Author information

1
Nanjing Research Institute for Comprehensive Utilization of Wild Plants, Nanjing 210042, P.R. China.
2
Key Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing 210038, P.R. China.

Abstract

A series of pentacyclic triterpenoids similar to glycyrrhetinic acid were designed and synthesized via the combination of chemical modification and microbial catalysis. All products were screened for the glycogen phosphorylases inhibitory activities in vitro. Within this series of derivatives, compound 5 displayed good inhibitory activities with IC50 value of 27.7 μM, which is better than that of the other derivatives and glycyrrhetinic acid. Structure-activity relationship (SAR) analysis of these inhibitors was also discussed.

KEYWORDS:

Aspergillus ochraceus CICC 40330; Biocatalysis; Streptomyces griseus ATCC 13273; glycyrrhetinic acid; oleanolic acid

PMID:
30562883
DOI:
10.4014/jmb.1804.04042
[Indexed for MEDLINE]

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