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Eur J Nutr. 2018 Jul 18. doi: 10.1007/s00394-018-1775-1. [Epub ahead of print]

Differences in the dietary requirement for vitamin D among Caucasian and East African women at Northern latitude.

Author information

1
School of Food and Nutritional Sciences, Cork Centre for Vitamin D and Nutrition Research, Cork, Ireland. k.cashman@ucc.ie.
2
Department of Medicine, University College Cork, Cork, Ireland. k.cashman@ucc.ie.
3
Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg C, Denmark.
4
Calcium Research Unit, Department of Food and Nutrition, University of Helsinki, Helsinki, Finland.
5
School of Food and Nutritional Sciences, Cork Centre for Vitamin D and Nutrition Research, Cork, Ireland.
6
Irish Centre for Fetal and Neonatal Translational Research [INFANT], University College Cork, Cork, Ireland.

Abstract

CONTEXT:

Current vitamin D recommendations have been established based on an assumption that there are no differences between Caucasian and other ethnic/racial groups in terms of vitamin D requirements. This assumption, largely made due to the absence of data, is a key knowledge gap identified by a number of authorities.

OBJECTIVE:

To test whether the distribution of dietary requirements for maintaining winter serum 25-hydroxyvitamin D [25(OH)D] concentrations ≥ 30 nmol/L (a priority threshold linked to vitamin D deficiency prevention) differ between Caucasian and Somali women living at northerly latitude.

METHODS:

We used data from a 5-month, winter-based, vitamin D3 dose-related randomized, placebo-controlled trial in Somali (n 47) and Causcian women (n 69), aged 21-64-year old, living in Southern Finland (60°N), to model the vitamin D intake-serum 25(OH)D dose-response relationship. Regression analyses were used to predict the vitamin D intake required to maintain 97.5% (as well as 50, 90, and 95%) of women in both ethnic groups above serum 25(OH)D thresholds of 30, 40 and 50 nmol/L.

RESULTS:

Using a model which adjusted for baseline 25(OH)D, age, and BMI, the estimated vitamin D intake that maintained serum 25(OH)D ≥ 30 nmol/L in 97.5% of Caucasian and Somali women was 8 and 18 µg/day, respectively. Ethnic differences were also evident at 40 and 50 nmol/L serum 25(OH)D thresholds.

CONCLUSION:

The present study adds further evidence that ethnic differences in the dietary requirement for vitamin D do exist and that dose-response vitamin D intervention studies are required in at-risk target populations specified by ethnicity.

KEYWORDS:

Dietary reference values; Ethnic-related differences; RCT; Vitamin D requirements

PMID:
30022296
DOI:
10.1007/s00394-018-1775-1

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