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Physiology, Urea Cycle.

Authors

Barmore W1, Stone WL2.

Source

StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019-.
2019 Jan 8.

Author information

1
Mercer University School of Medicine
2
East Tennessee State University

Excerpt

The liver catabolizes toxic ammonia into urea as shown in Figure 1.  This energy-dependent process occurs only within the liver’s mitochondria and cytoplasm. When this process is not working efficiently, toxic ammonia (NH3) accumulates within the body and may elicit clinical manifestations such as lethargy, slurred speech, cerebral edema, and asterixis. Here, we will review the underlying physiology of the urea cycle.[1][2][3]

Copyright © 2019, StatPearls Publishing LLC.

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