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Muscle Nerve. 2018 Dec;58(6):796-800. doi: 10.1002/mus.26300. Epub 2018 Nov 8.

Factors predicting remission in thymectomized patients with acetylcholine receptor antibody-positive myasthenia gravis.

Author information

1
Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Seoul, Republic of Korea.

Abstract

INTRODUCTION:

Although thymectomy is an important therapeutic option for myasthenia gravis (MG), factors predicting remission after thymectomy are not well known.

METHODS:

We retrospectively reviewed patients with acetylcholine receptor antibody (AChR-Ab)-positive MG who had undergone thymectomy. Prognostic factors predicting remission were investigated. Changes in AChR-Ab titer before and after thymectomy were also evaluated.

RESULTS:

Among the 179 patients, 52.5% achieved complete stable or pharmacologic remission. Nonthymomatous pathology and mild preoperative status were favorable predictors of remission. The decrease in AChR-Ab titer after thymectomy was significant in nonthymomatous MG but not in thymomatous MG.

DISCUSSION:

Nonthymomatous pathology and mild preoperative status are prognostic factors that may predict remission after thymectomy. The decrease in AChR-Ab titer after thymectomy was significant in nonthymomatous MG but not in thymomatous MG, suggesting that the pathogenic role of the thymus differs according to pathology. Muscle Nerve 58:796-800, 2018.

KEYWORDS:

acetylcholine receptor antibody; myasthenia gravis; prognostic factors; thymectomy; thymic pathology; thymoma

PMID:
30020542
DOI:
10.1002/mus.26300
[Indexed for MEDLINE]

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