Format

Send to

Choose Destination
Prev Nutr Food Sci. 2018 Jun;23(2):102-107. doi: 10.3746/pnf.2018.23.2.102. Epub 2018 Jun 30.

Phaseolus vulgaris Exerts an Inhibitory Effect on Platelet Aggregation through AKT Dependent Way.

Author information

1
Centro de Estudios en Alimentos Procesados (CEAP), CONICYT-regional, Gore Maule, Talca R09I2001, Chile.
2
Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, University of Talca, Talca 3465548, Chile.
3
Programa de Investigación Asociativa en Cáncer Gástrico (PIA-CG), University of Talca, Talca 3465548, Chile.

Abstract

The Phaseolus vulgaris (common bean), a worldwide vegetable of high consumption, can act as a nutritional supplement in the diet of oversized individuals to reduce weight. Studies have demonstrated the existence of molecules capable of inhibiting the breakdown of carbohydrates via inhibition of both α-amylases and glycosidases. Here, we describe a novel property of the Phaseolus vulgaris: inhibition of thrombotic cardiovascular events. Using assays to test platelet aggregation and secretion, and flow cytometry against the surface expression of P-Selectin. We show that bean extracts significantly reduced adenosine 5'-diphosphate and arachidonic acid induced-platelet aggregation. The mechanism underlying such effect appears to be mediated by AKT, since AKT hypo-phosphorylation decreases the "inside out" activation of platelets. In sum, our results support the hypothesis that common beans are nutritional ingredients that help reduce the risk of cardiovascular diseases associated with platelet hyper-reactivity.

KEYWORDS:

AKT; Phaseolus vulgaris; cardiovascular diseases; extracts; platelets aggregation

Conflict of interest statement

AUTHOR DISCLOSURE STATEMENT The authors declare no conflict of interest.

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center