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Am J Transl Res. 2018 Jun 15;10(6):1852-1859. eCollection 2018.

Quantitative measurement of breast carcinoma fibrosis for the prediction in the risk of bone metastasis.

Author information

1
Department of Orthopedics, The Affiliated Hospital of Qingdao University Qingdao, Shandong, China.
2
Department of Radiology, Feinberg School of Medicine, Northwestern University Chicago, IL, USA.
3
Department of Orthopedics, Qilu Hospital, Shandong University Jinan, Shandong, China.
4
Robert H. Lurie Comprehensive Cancer Center Chicago, IL, USA.

Abstract

BACKGROUND:

Previous studies have shown the poor prognosis of metastatic breast cancer including bone metastasis. The early prediction and intervention of invasive breast carcinoma with bone metastasis are crucial to the outcomes of patients. The purpose of our study is to test the hypothesis that the collagen deposition of primary breast cancer can be used as a quantitative biomarker for the early prediction of bone metastasis.

METHODS:

A total of sixty breast cancer patients were included in our study, and the surgical specimens of these patients were divided into three groups: patients with no metastasis (group 1), lymph node metastasis (group 2), and bone metastasis (group 3). Masson's trichrome staining and hematoxylin and eosin staining were applied to all primary breast cancers. Collagen area percentage and tumor cell measurement of each sample were measured by HistoQuest software.

RESULTS:

Measurement results of collagen area percentage (%) in primary breast tumors were 32.39 ± 13.30, 25.37 ± 11.10, and 22.71 ± 8.91 for groups 1, 2, and 3, respectively. The corresponding P values were 0.0779 (group 1 vs. group 2), 0.4086 (group 2 vs. group 3), and 0.0102 (group 1 vs. group 3). The correlation between collagen area percentage and tumor cell measurement were group 1 (P = 0.5927, r = -0.1273), group 2 (P = 0.5711, r = -0.1348), and group 3 (P = 0.0003, r = -0.7253).

CONCLUSIONS:

The collagen deposition of primary breast cancer can be used as a quantitative biomarker for the early prediction of bone metastasis.

KEYWORDS:

Invasive breast carcinoma; bone metastasis; collagen deposition; early prediction

PMID:
30018725
PMCID:
PMC6038064

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