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Behav Neurol. 2018 Jun 19;2018:9421098. doi: 10.1155/2018/9421098. eCollection 2018.

REM Sleep Behavior Disorder (RBD) in Dementia with Lewy Bodies (DLB).

Chan PC1, Lee HH2,3,4,5, Hong CT2,3, Hu CJ2,3,5, Wu D2,3,4.

Author information

1
Department of Neurology, Show Chwan Memorial Hospital, Changhua, Taiwan.
2
Department of Neurology, Taipei Medical University Shuang Ho Hospital, New Taipei City, Taiwan.
3
Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
4
Sleep Center, Taipei Medical University Shuang Ho Hospital, New Taipei City, Taiwan.
5
Vertigo and Balance Impairment Center, Taipei Medical University Shuang Ho Hospital, New Taipei City, Taiwan.

Abstract

Rapid eye movement sleep behavior disorder (RBD) is a parasomnia, with abnormal dream-enacting behavior during the rapid eye movement (REM) sleep. RBD is either idiopathic or secondary to other neurologic disorders and medications. Dementia with Lewy bodies (DLB) is the third most common cause of dementia, and the typical clinical presentation is rapidly progressive cognitive impairment. RBD is one of the core features of DLB and may occur either in advance or simultaneously with the onset of DLB. The association between RBD with DLB is widely studied. Evidences suggest that both DLB and RBD are possibly caused by the shared underlying synucleinopathy. This review article discusses history, clinical manifestations, possible pathophysiologies, and treatment of DLB and RBD and provides the latest updates.

PMID:
30018672
PMCID:
PMC6029467
DOI:
10.1155/2018/9421098
[Indexed for MEDLINE]
Free PMC Article

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