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J Agric Food Chem. 2018 Aug 15;66(32):8522-8529. doi: 10.1021/acs.jafc.8b01522. Epub 2018 Jul 31.

Phycobiliproteins Production Enhancement and Lipidomic Alteration by Titanium Dioxide Nanoparticles in Synechocystis sp. PCC 6803 Culture.

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College of Pharmacy , Chung-Ang University , Seoul 06974 , Republic of Korea.
Institute of Environmental Sciences and Engineering, School of Civil and Environmental Engineering , National University of Sciences and Technology , Sector H-12 , Islamabad 44000 , Pakistan.
Department of Chemical Engineering and Applied Chemistry , Chungnam National University , Daejeon 34134 , Republic of Korea.
Institute of Industrial Biotechnology, Department of Biological Engineering , Inha University , Incheon 22212 , Republic of Korea.
Department of Biological Sciences , KAIST , Daejeon 34141 , Republic of Korea.
College of Pharmacy , Gachon University , Incheon 13120 , Republic of Korea.


This study aimed to improve the production of phycobiliproteins using TiO2 nanoparticles (NPs) in Synechocystis sp. PCC 6803. The growth characteristics of Synechocystis cells were not affected by TiO2 NPs treatment, but this treatment increased the chlorophyll content significantly by 62.2% (14.6 mg/L) compared to that of control (9.0 mg/L) on day 16. Phycocyanin production was increased by 33.8% (29.3 g/L) compared to that of control (21.9 g/L) on day 8. Allophycocyanin production was increased by 55.0% (6.2 g/L) compared to that of control (4.0 g/L) on day 8, and by 22.4% (16.4 g/L) compared to that of control (13.4 g/L) on day 16. Direct infusion mass spectrometry revealed that TiO2 NPs treatment significantly increased the levels of major thylakoid membranes of monogalactosyldiacylglycerols (18:2/18:3, 18:2/18:2, 18:1/18:2), phosphatidylglycerol (16:0/16:1), and sulfoquinovosyldiacylglycerols (16:0/16:1, 16:0:18:4) on day 8. These findings indicate that TiO2 NPs have potential for commercial applications in Synechocystis species or other microalgal strains.


DI-MS; Synechocystis sp. PCC 6803; TiO2 nanoparticles; phycobiliproteins

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